FRAT®
What are FRAAs?
Folate Receptor Autoantibodies, shorted to FRAAs, are antibodies made by the body’s immune system which mistakenly attack the body’s own folate receptors.
Folate receptors normally transport folate (also called vitamin B9) from the bloodstream into the brain. When receptors are blocked or damaged by FRAAs, folate has trouble crossing the blood-brain barrier, and the level of folate in the brain can become low even if levels in the body appear normal. Folic acid supplementation may not be able to bypass this blockage.



